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The procedures used to isolate and analyze the parent and daughter nuclides must be precise and accurate.

This normally involves isotope-ratio mass spectrometry. The precision of a dating method depends in part on the half-life of the radioactive isotope involved.

For example, the age of the Amitsoq gneisses from western Greenland was determined to be Accurate radiometric dating generally requires that the parent has a long enough half-life that it will be present in significant amounts at the time of measurement (except as described below under "Dating with short-lived extinct radionuclides"), the half-life of the parent is accurately known, and enough of the daughter product is produced to be accurately measured and distinguished from the initial amount of the daughter present in the material.The possible confounding effects of contamination of parent and daughter isotopes have to be considered, as do the effects of any loss or gain of such isotopes since the sample was created.It is therefore essential to have as much information as possible about the material being dated and to check for possible signs of alteration.In these cases, usually the half-life of interest in radiometric dating is the longest one in the chain, which is the rate-limiting factor in the ultimate transformation of the radioactive nuclide into its stable daughter.Isotopic systems that have been exploited for radiometric dating have half-lives ranging from only about 10 years (e.g., tritium) to over 100 billion years (e.g., samarium-147).

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