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The opposite of LTP is long-term depression, which produces a long-lasting decrease in synaptic strength.It is one of several phenomena underlying synaptic plasticity, the ability of chemical synapses to change their strength.The pyramid, representing the investor's portfolio, has three distinct tiers: Not all investors are created equal.

On the lower portion are much safer investments, but these investments have a lower potential for high returns.As memories are thought to be encoded by modification of synaptic strength, LTP was discovered in the rabbit hippocampus by Terje Lømo in 1966 and has remained a popular subject of research since.Many modern LTP studies seek to better understand its basic biology, while others aim to draw a causal link between LTP and behavioral learning.In his 1894 Croonian Lecture, he proposed that memories might instead be formed by strengthening the connections between existing neurons to improve the effectiveness of their communication.Hebbian theory, introduced by Donald Hebb in 1949, echoed Ramón y Cajal's ideas, further proposing that cells may grow new connections or undergo metabolic changes that enhance their ability to communicate: Let us assume that the persistence or repetition of a reverberatory activity (or "trace") tends to induce lasting cellular changes that add to its stability....

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